Background: To identify risk factors for being a ââ?¬Å?reduced responderââ?¬Â to ranibizumab treatment in a clinical setting\r\nin patients with neovascular age-related macular degeneration.\r\nMethods: This retrospective study included 165 eyes of 165 consecutive patients with choroidal neovascularisation\r\nsecondary to neovascular, age-related macular degeneration. Eyes were treated with three intravitreal injections of\r\nranibizumab, followed by PRN (pro re nata) dosing thereafter. All patients were reevaluated every four weeks and\r\nthen followed for six months. Reduced responders were defined as patients with a loss in visual acuity of at least 1\r\nvisual acuity line at the last follow-up and/or persistent intraretinal or subretinal fluid or detectable choroidal\r\nneovascularisation at the last follow-up, compared to baseline.\r\nResults: Overall, 58 out of 165 eyes (35.2%) were considered to be reduced responders to treatment at the end of\r\nfollow-up. The initial CNV size at baseline was correlated with the risk of being a reduced responder at the end of\r\nfollow-up (p = 0.017).\r\nConclusion: We identified the initial lesion size as a predictor for a reduced response to treatment in this study.\r\nPatients with a large initial lesion size should be thoroughly informed about the possible poorer response to the\r\nintravitreal treatment.
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